Changes in cortical inhibition during task‐specific contractions in primary writing tremor patients
Identifieur interne : 003538 ( Main/Exploration ); précédent : 003537; suivant : 003539Changes in cortical inhibition during task‐specific contractions in primary writing tremor patients
Auteurs : Milos Ljubisavljevic [Serbie, Émirats arabes unis] ; Aleksandra Kacar [Serbie] ; Sladjan Milanovic [Serbie] ; Marina Svetel [Serbie] ; Vladimir S. Kostic [Serbie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-06-06.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Contraction, Dystonic Disorders (physiopathology), Dystonic Disorders (therapy), Electromyography, Functional Laterality, Human, Humans, Middle Aged, Motor Activity (physiology), Motor Cortex (physiopathology), Muscle Contraction (physiology), Nervous system diseases, Reference Values, Silent period, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Treatment Outcome, Tremor, Tremor (etiology), Tremor (physiopathology), cortical inhibition, primary writing tremor, silent period, transcranial magnetic stimulation.
- MESH :
- etiology : Tremor.
- physiology : Motor Activity, Muscle Contraction.
- physiopathology : Dystonic Disorders, Motor Cortex, Tremor.
- therapy : Dystonic Disorders.
- Adult, Age of Onset, Aged, Electromyography, Functional Laterality, Humans, Middle Aged, Reference Values, Transcranial Magnetic Stimulation, Treatment Outcome.
Abstract
Primary writing tremor (PWT) is a rare disease of unknown pathophysiology. We studied changes in silent period (SP) duration, after transcranial magnetic stimulation (TMS), set at 20% above the motor threshold in 6 PWT patients and 7 healthy control subjects. SP duration was tested during a task‐specific act, i.e., writing that induced tremor in all patients in the affected hand (Wr); nonspecific voluntary contraction of intensity, matching that developed during writing (VCWr); and during near maximal voluntary contraction (VCNmax). There were no differences in SP duration during Wr and VCWr contraction on the right affected side or between sides in both PWT patients and control subjects, nor between the groups. However, during VCNmax, SP significantly shortened on both sides in PWT patients, whereas there were no changes in control subjects. Although it appears that inhibitory mechanism are not directly involved in the generation of the tremulous activity, the shortening of SP indicates that central inhibitory mechanisms are affected in PWT patients. Therefore, whereas the underlying pathophysiological mechanisms in PWT and writer's cramp may share common features, the results indicate that PWT is not a variant of focal task‐specific dystonia but rather a separate nosological entity. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20807
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-06-06">2006-06-06</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="855">855</biblScope><biblScope unit="page" to="859">859</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">52F3D4CEB6CDA4CCDC80FF2D08FE03B0A00EBB9E</idno><idno type="DOI">10.1002/mds.20807</idno><idno type="ArticleID">MDS20807</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Contraction</term><term>Dystonic Disorders (physiopathology)</term><term>Dystonic Disorders (therapy)</term><term>Electromyography</term><term>Functional Laterality</term><term>Human</term><term>Humans</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Motor Cortex (physiopathology)</term><term>Muscle Contraction (physiology)</term><term>Nervous system diseases</term><term>Reference Values</term><term>Silent period</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>Treatment Outcome</term><term>Tremor</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term><term>cortical inhibition</term><term>primary writing tremor</term><term>silent period</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term><term>Muscle Contraction</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term><term>Motor Cortex</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Electromyography</term><term>Functional Laterality</term><term>Humans</term><term>Middle Aged</term><term>Reference Values</term><term>Transcranial Magnetic Stimulation</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Contraction</term><term>Homme</term><term>Période muette</term><term>Stimulation magnétique transcrânienne</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary writing tremor (PWT) is a rare disease of unknown pathophysiology. We studied changes in silent period (SP) duration, after transcranial magnetic stimulation (TMS), set at 20% above the motor threshold in 6 PWT patients and 7 healthy control subjects. SP duration was tested during a task‐specific act, i.e., writing that induced tremor in all patients in the affected hand (Wr); nonspecific voluntary contraction of intensity, matching that developed during writing (VCWr); and during near maximal voluntary contraction (VCNmax). There were no differences in SP duration during Wr and VCWr contraction on the right affected side or between sides in both PWT patients and control subjects, nor between the groups. However, during VCNmax, SP significantly shortened on both sides in PWT patients, whereas there were no changes in control subjects. Although it appears that inhibitory mechanism are not directly involved in the generation of the tremulous activity, the shortening of SP indicates that central inhibitory mechanisms are affected in PWT patients. Therefore, whereas the underlying pathophysiological mechanisms in PWT and writer's cramp may share common features, the results indicate that PWT is not a variant of focal task‐specific dystonia but rather a separate nosological entity. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Serbie</li><li>Émirats arabes unis</li></country></list><tree><country name="Serbie"><noRegion><name sortKey="Ljubisavljevic, Milos" sort="Ljubisavljevic, Milos" uniqKey="Ljubisavljevic M" first="Milos" last="Ljubisavljevic">Milos Ljubisavljevic</name></noRegion><name sortKey="Kacar, Aleksandra" sort="Kacar, Aleksandra" uniqKey="Kacar A" first="Aleksandra" last="Kacar">Aleksandra Kacar</name><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name><name sortKey="Milanovic, Sladjan" sort="Milanovic, Sladjan" uniqKey="Milanovic S" first="Sladjan" last="Milanovic">Sladjan Milanovic</name><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name></country><country name="Émirats arabes unis"><noRegion><name sortKey="Ljubisavljevic, Milos" sort="Ljubisavljevic, Milos" uniqKey="Ljubisavljevic M" first="Milos" last="Ljubisavljevic">Milos Ljubisavljevic</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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